AGI May 41/5
نویسندگان
چکیده
Abely, M., P. Dallet, M. Boisset, and J. F. Desjeux. Effect of cholera toxin on glutamine metabolism and transport in rabbit ileum. Am J Physiol Gastrointest Liver Physiol 278: G789–G796, 2000.—The aim of the present study was to evaluate the effect of cholera toxin on energy balance from intestinal glutamine metabolism and oxidation, glutaminedependent sodium absorption, and cholera toxin-dependent ion flux. Cholera toxin-stimulated sodium and L-glutamine ileal transport and metabolism were studied in Ussing chambers. Glutamine (10 mM) transport and metabolism were simultaneously studied using 14C flux and HPLC. In the same tissues, the flux of each amino acid was studied by HPLC, and glutamine metabolism and oxidation were studied by the determination of amino acid specific activity and CO2 production. In control tissues, glutamine stimulated sodium absorption and was mainly oxidized. The transepithelial flux of intact glutamine represented 45% of glutamine flux across the luminal membrane. The other metabolites were glutamate and, to a lesser degree, citrulline, ornithine, and proline. Cholera toxin did not alter glutamine-stimulated sodium absorption, glutamine oxidation, transport, and metabolism. In conclusion, the present results indicate that cholera toxin does not alter glutamine intestinal function and metabolism. In addition, ,95% of the energy provided by glutamine oxidation remains available to the enterocyte.
منابع مشابه
AGI May 41/5
NICOLA L. JONES,1,2,3 AVINASH ISLUR,1 RIZWAN HAQ,4 MARIOLA MASCARENHAS,1 MOHAMED A. KARMALI,2 MARY H. PERDUE,5 BRENT W. ZANKE,4 AND PHILIP M. SHERMAN1,2,3 1Research Institute, Hospital for Sick Children, and Departments of 2Molecular Microbiology and Medical Genetics and 3Pediatrics, University of Toronto, Toronto M5G 1X8; 4Department of Medicine, University of Toronto, Princess Margaret Hospit...
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